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| onto cancerous cells, restoring the cell's electrostatic order and activating the formation of surveillance steroids. Squalene is especially indicated for those cancers of a herpes virus originfor example, cervical cancer. Squalene possesses antiviral as well as anticancer activity. |
| Even in cases where sharks are exposed to aflatoxin B1, the most potent naturally occuring liver-cancer-causing agent known, squalene protects them against cancer. Squalene is an individually resolved component of shark liver oil. This ubiquitous compound is a metabolite of sterol synthesis and is also found in human tissues and plasma. Squalene also activates the key antioxidant enzyme, glutathione transferase. Squalene has been examined for its ability to potentiate the cytotoxicity and antitumor activity of anticancer therapies, such as Adriamycin, 5-FU, and cis-platinum, in vivo and in vitro. The antitumor activities of these anticancer agents combined with squalene were tested against sarcoma 180 ascite cells. This combination of anticancer agents with membrane-active agents is useful because it can overcome drug resistance and inhibit the development of drug-resistant tumors. |
| Studies have reported antitumor activity of highly purified squalene in murine transplantable tumor systems. In cancer immunotherapy, augmentation of tumor-specific (as well as nonspecific) immunity is critically important. Olive oil is also very rich in squalene, and, in fact, most commercial squalene products are derived from olive oil. 114 |
| Squalene has an enhancing effect on cellular oxygen uptake, which produces a more efficient metabolism at the cellular level. By inhibiting fatty acid lipid peroxidation, it offers protection from the sun when used externally. Squalene and shea butter are two of the best fatty acids to use for protecting skin from aging, sun damage, and skin cancer. Using these fatty acids externally and at the same time taking plant antioxidants internally, such as green tea, turmeric, hawthorn, St. John's wort, lavender, or rosemary along with a full-spectrum carotenoid supplement, ascorbate vitamin C, dry vitamin E, and selenium, supplies the body with nutrients that are protection against skin cancer as well as other cancers and chronic illnesses. |
| Another recent study has demonstrated that squalamine, asteroid derived from shark liver, inhibits angiogenesis and tutor growth in multiple animal models and may be well suited for treatment of tumors and other diseases characterized by neovascularization in humans.115 |
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