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| calcium salt of D-glucaric acid, a naturally occurring substance found in humans and many plants that is an important detoxifying agent because of its effects on glucuronidation. |
| CDG works by metabolizing an excess of estrogen in the body. Normally, estrogen is metabolized in the liver and the body rids itself of estrogen by passing it through the liver, where it hooks onto a conjugate called glucuronic acid and passes out with the stool. This process, called glucoronidation, is the way the body detoxifies and deans house. |
| Under normal healthy conditions, which must include low levels of liver stress and good sleep patterns, the glucuronide conjugate passes From the liver into the bile and then into the gut, where it is dispersed and ultimately eliminated through the bowel. Sometimes there are high levels of an enzyme called beta-glucuronidase that rip the glucuronide conjugate off the estrogen. Then the estrogen is free to be reabsorbed back into the bloodstream in a more oxidized, reactive, cancer-promoting form. CDG stops the glucuronidase from freeing the estrogen for reabsorptiona very important step in stopping this dangerous process. |
| Glucuronidation is part of the Phase II conjugation pathway of the liver, which detoxifies and excretes not only estrogen but xenobiotics, lipid-soluble toxins, and other steroid hormones, all of which can act as promoting agents to cancer. |
| One important effect of taking CDG orally is that it reduces serum estrogen levels, which in turn inhibits breast tumors. In addition to preventing breast cancer (as well as other hormone-related cancers), CDG can inhibit the recurrence of cancer and be part of a protocol for the treatment of cancer. 87,88 |
| I presently suggest doses of 2 to 4 capsules (500 mg each) two to three times daily. |
| Flavonoids |
| Flavonoids are brightly colored substances commonly found in most plants. They account for a significant percentage of the chemical constituents of those plants and are usually found alongside vitamin C in nature. Both substances were discovered by Albert Szent-Gyorgyi and isolated from paprika in the 1930s. Szent-Gyorgyi himself called bioflavonoids ''vitamin P'' and suggested they were crucial for the integrity of the small blood vessels and as |
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